Treatment of comorbid anxiety symptoms and insomnia in patients with schizophrenia: A review of Pros and Cons.

Introduction Recent studies report a prevalence of comorbid anxiety disorder 38% and 80% sleep disorders in schizophrenia. Insomnia has been associated with worsening psychopathological symptoms increased hospitalization rates. Objectives The aim our work was to review mechanisms action the use benzodiazepines, GABAergic drugs melatonin for treatment insomnia Methods We carried out narrative focusing on schizophrenia through PubMed Google Scholar (2002-September 2022). are discussed, illustrating them case reports. Results A total 32 were included. (A)Benzodiazepines (BZD) facilitating inhibitory actions gamma-aminobutyric acid (GABA) by binding GABA type receptors. beneficial effect combined antipsychotics BZD is controversial (cognitive complications, sedation, overdosing, substance use, etc). (B)GABAergic drugs: gabapentin (GP) pregabalin (PG) (structurally related molecules), have no direct act inhibiting voltage-gated calcium channels. efficacy GP PG understudied. Positive effects suffering from restless legs syndrome receiving clozapine. (C )Melatonin, an hormone produced pineal gland used treat insomnia. metabolic cardiovascular risk factors reported. Several works considered it alternative Conclusions Few evidence available BZD, GP, Melatonin promising compound Disclosure Interest None Declared